Acute Oral Toxicity Potential of 4-Nitrophenyl Methkyl Phenyl Phosphinate.
Abstract
The acute oral toxicity potential of 4-nitrophenyl methyl phenyl phosphinate was tested in rats exposed to dose levels ranging from vehicle control (Tween 80, ethanol, citrate buffer and water) to 60 mg/kg body weight. Probit analysis was used to derive values for the median lethal dose LD50. Animals were dosed once and observed for 14 days. The LD50 for males was 34.0 mg/kg, with a 95% confidence range of 24.1-48.0 mg/kg. The LD50 for females was 12.5 mg/kg, with a 95% confidence range of 7.2-21.6 mg/dk. The toxicity of this material is in the high range. Planned human use experimentation is warranted. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1982
- Accession Number
- ADA121876
Entities
People
- John T. Fruin
- Martha A. Hanes
- Thomas P. Kellner
Organizations
- Letterman Army Hospital