Synthesis of New Prophylactic Antiradiation Drugs.
Abstract
This report presents details of the work done on the project (covered) during the last 12 months. Approaches to the synthesis of a number of 3-aryl l-(omega-aminoalkyl) adamantanes is described. Their final incorporation in the preparation of N-(adamantylalkyl) alpha-mercapto acetamidines, and derivatives, as potential antiradiation drugs is projected. The report divided into two major sections. The first dealls with the preparation of 1,3-bis(2-aminoethyl) adamantane and its conversion to the disulfide of 1,3-bis(2-(mercaptomethylcarboxamidino) ethyl)-adamantane. The next section describes the synthesis of some 3-aryl-l-adamantanecarboxylic and acetic acids, 12 (n=0 or 1, respectively). These are the vital precursors needed for the synthesis of the essential 3-aryl (l-adamantylmethyl and ethylamines), 11, which will be a part of the N-substituent of the target alpha-mercaptoacetamidines and derivatives, Adm(CH2)nHNC(=NH)CH2SH. (Adm standing for a 3-aryl-l-adamantyl group).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1981
- Accession Number
- ADA122649
Entities
People
- Ludwig Bauer
Organizations
- University of Illinois Urbana–Champaign