Molecular Toxicology of Chromatin

Abstract

The patho-biological function of the nuclear homopolymer; poly ADP- ribose is being studied. It was found that this homopolymer, that has been identified recently by us to be a unique nucleic acid, with helical conformation, and is covalently bound to prevalently non histone chromatin proteins, exhibits specific quantitative signals during aging differentiation and precancerous perturbations.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1982
Accession Number
ADA123222

Entities

People

  • Ernest Kun

Organizations

  • University of California, San Francisco

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Acids
  • Air Force
  • Amides
  • California
  • Cancer
  • Carcinogens
  • Chemistry
  • Chromosome Structures
  • Hypertrophy
  • Identification
  • Neoplasms
  • Nucleic Acids
  • Pharmacology
  • Polymers
  • Proteins
  • Toxicology
  • Universities

Fields of Study

  • Chemistry

Readers

  • Molecular and Cellular Biochemistry

Technology Areas

  • Biotechnology