Studies on the Enzymatic Hydrolysis of Organophosphate Poisons in Pigs.

Abstract

Phosphate paraoxon was studied in Yorkshire pig, rat and human sera. Enzymatic hydrolysis was significantly affected by certain buffers in the reaction mixture. Kinetic measurements suggest that more than one enzyme hydrolyzes the organophosphate. Depending on pH and substrate concentration, inhibition of the enzymes by paraoxon is or is not observed. Enzymatic activity in human serum increases with a rise in pH whereas in pig serum activity decreases. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1982
Accession Number
ADA123269

Entities

People

  • June Jaeger
  • Peter J. Schmid

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Blood
  • Blood Proteins
  • California
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Materials
  • Military Research
  • Organophosphates
  • Poisoning
  • Spectra
  • Standards
  • Time Intervals
  • United States
  • Warfare

Readers

  • Organic Chemistry
  • Toxicology/Environmental Toxicology