Evaluation of Dimethyl Methylphosphonate and Exo-Tetrahydrodi- (Cyclopentadiene) in a Battery of in Vitro Short-Term Assays

Abstract

Dimethyl methylphosphonate (DMMP) and exo-tetrahydrodi- (cyclcpentadiene) (JP-10), two compounds of interest to the United States Air Force, were evaluated in a battery of five in vitro short-term assays to assess their potential biological activity. The assays conducted include the Ames Salmonella/mammalian microsomal mutagenicity assay, the CHO/HGPRT gene mutation assay, the CHO/sister chromatid exchange assay, the CHO/chromosome aberrations assay, and the BALB/c-3T3 neoplastic transformation assay. In the absence of an exogenous metabolic activation system, DMMP exhibited a low clastogenic activity in the CHO/chromosome aberrations assay and was negative in the remaining four assays. Compound JP-10 also had a marginal clastogenic effect in the CHO/ chromosome aberrations assay and produced a negative (or inconclusive) response in the other assays conducted. In the presence of an S-9 fraction, DMMP produced no mutagenic response in the Ames Salmonella mutagenicity assays. Results on JP- 10 were inconclusive.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1983
Accession Number
ADA124785

Entities

People

  • Andrew Sivak

Organizations

  • Arthur D. Little

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acceptability
  • Air Force
  • Alcohols
  • Bacteria
  • Biomedical Research
  • Cell Line
  • Chromosome Aberrations
  • Culture Techniques
  • Data Analysis
  • Materials
  • Methanols
  • Plastic Explosives
  • Standards
  • Statistical Analysis
  • Test And Evaluation
  • Toxic Hazards
  • Toxicity

Fields of Study

  • Biology

Readers

  • Electrochemical Engineering/ Fuel Cell Technologies
  • Toxicology/Environmental Toxicology