Toxicity Studies of Formaldehyde Monomethylhydrazone
Abstract
The toxicity of formaldehyde monomethylhydrazone (FMH) has been studied. The LD50 of FMH in the mouse was 42 mg/kg. Signs of acute toxicity were tremors and violent convulsions. Pyridoxine effectively prevented these convulsions. Reaction of FMH and DMBA appears similar to monomethylhydrazine (MMH) suggesting past errors in quantitating MMH using the spectrophotometric method. The high dose group (20 mg/kg) of mice in the short term toxicity study had an elevated serum aspartate aminotransferase (SGOT) but did not develop demonstratable histopathologic lesions involving the liver.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1983
- Accession Number
- ADA125539
Entities
People
- John P. Murphy
- K. C. Back
- M. E. Andersen
- R. H. Bruner
- William C. Keller
Organizations
- Air Force Research Laboratory