Fourteen-Day Feeding Study of 2,4-Dinitrotoluene in Male and Female Rats

Abstract

The purpose of this study was to obtain preliminary data in rats concerning effects of 2,4-dinitrotoluene (DNT) on tissue histology, blood chemistry, hematology, and urinary parameters. Male and female rats were fed a laboratory chow diet to which was added 0, 1.0, 1.5, 2.5, and 3.5 g DNT/kg. After 14 days, the animals were fasted in metabolic cages, killed, and necropsies were performed. No DNT-related effects were found on blood hematology or urinary parameters. Blood cholesterol was elevated in all groups receiving DNT. A dose-dependent elevation in blood glucose was observed in both sexes, but the effect was statistically significant only in the females. Alanine aminotransferase was elevated in all male groups fed the compound. DNT induced the development of hyaline droplets in the epithelium of the proximal convoluted tubules of the kidneys of both males and females. Oligospermatism with degenerative changes in the testes of male rats was observed in a dose-dependent response.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1983
Accession Number
ADA126069

Entities

People

  • Evelyn L. Mcgown
  • George T. Makovec
  • Glen E. Marrs Jr
  • John J. Knudsen

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  • Letterman Army Hospital

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  • Biomedical

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  • Biological Sciences
  • Biomedical Research
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  • Histology
  • Leukocytes
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  • Tissues

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  • Toxicology/Environmental Toxicology