Mediators of Fever and Muscle Proteolysis,
Abstract
This is an invited editorial for the New England Journal of Medicine which discusses a new finding, i.e., that a mediator released by phagocytic cells during severe trauma or infection serves to initiate proteolysis of skeletal muscle. The mediator causes PGE2 formation in muscle which in turn activates lysosomal proteases. The importance of this sequence is discussed in terms of host survival and defensive mechanisms. Interrelationships among the mediators are also discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 27, 1983
- Accession Number
- ADA126178
Entities
People
- William R. Beisel
Organizations
- United States Army Medical Research Institute of Infectious Diseases