Development of Monoclonal Antibodies to Trypanosoma brucei rhodesiense Antigens.
Abstract
This report, describes methodology of tissue culture, hybridization procedures, immunization schedules and antibody assays developed to produce monoclonal antibodies to variant specific surface antigens of Trypansoma b. rhodesiense organisims of the Walter Reed Army Trypanozoon antigenic type (WRATat) serodeme. Monoclonal antibodies have been produced to WRATat 3 and 5. A laboratory has been developed for the ongoing production of monoclonal antibody reagents to Trypanosomes. These reagents will be critical in assessment of antigenic variation and in potential vaccine development programs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1980
- Accession Number
- ADA126760
Entities
People
- Gary H. Campbell
- Janis Giorgi
Organizations
- University of New Mexico