Acute Effects of Anticholinesterase Agents on Pupillary Function.

Abstract

The strategy of this investigation was to correlate closely any impairment of pupillary function to parameters of cholinergic function in vitro and in vivo, following topical or systemic administration of antiChEs. The study focused upon three aspects of cholinergic function: the synthesis and turnover of ACh, the cholinergic receptor and the release of ACh. A schematic diagram of the various steps involved in the analysis of multiple parameters of acetylcholine metabolism in a single isolated iris is reported. The characteristics of the high and low affinity Ch uptake system which have been previously described for the developing and aging avian iris (Marchi et al., Dev. Neurosci. 3, 185, 1980 and Brain Res. 195, 423, 1980) have now been determined for the adult rat iris.

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Document Details

Document Type
Technical Report
Publication Date
Mar 29, 1983
Accession Number
ADA128434

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People

  • Ezio Giacobini

Organizations

  • University of Connecticut

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DTIC Thesaurus Topics

  • Abstracts
  • Acetylcholinesterases
  • Air Force
  • Cells
  • Cholinergic Nerves
  • Classification
  • Connecticut
  • Diagrams
  • Diameters
  • Enzyme Inhibitors
  • Inhibition
  • Metabolism
  • Peripheral Nervous System
  • Schematic Diagrams
  • Security
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  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry
  • Neurotoxicology