Antiviral Efficacy of Pyrazofurin against Selected RNA Viruses

Abstract

The antibiotic pyrazofurin, -(Beta-D-ribofuranosyl)-4-hydroxypyrazole-5-carboxamide, markedly inhibited the in vitro replication of a number of RNA viruses including Rift Valley Fever (RVF), Venezuelan equine encephalomyelitis (VEE), Sandfly, Pichinde, Lassa, and LCM virus. Plaque formation was reducted by 80% or more with 2-10 micrograms/ml of pyrazofurin while 2 migrograms/ml reduced by 1000-fold the yield of Lassa and LCM virus in a yield reduction assay. In vivo, pyrazofurin failed to protect mice and guinea pigs against a letal challenge with VEE and Pichinde virus, respectively. On the other hand, pyrazofurin caused a slight decrease in the mean time to death of mice infeced with RVF virus.

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Document Details

Document Type
Technical Report
Publication Date
Mar 24, 1982
Accession Number
ADA129381

Entities

People

  • P. B. Jahrling
  • P. G. Canonico
  • W. L. Pannier

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Antiviral Agents
  • Arbovirus Infections
  • Bunyaviridae
  • Cells
  • Diseases And Disorders
  • Infection
  • Infectious Diseases
  • Laboratory Animals
  • Phlebotomus Fever
  • Rift Valley Fever
  • Rift Valleys
  • Rna Viruses
  • Rodents
  • Tissue Culture
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology

Readers

  • Virology (or Medical Virology).