Acute Clinical Malaria (Plasmodium inui) in a Cynomolgus Monkey (Macaca fascicularis)

Abstract

Acute clinical malaria caused by Plasmodium inui was diagnosed in an adult female cynomolgus monkey (Macaca fascicularis) 4 years after importation into the United States. Stress and immunosuppression associated with experimentation completed 2 weeks earlier may have contributed to the development of severe clinical disease. Clinical findings included severe regenerative anemia, hepatosplenomegaly, weakness, lethargy, weight loss, and anorexia. The infection was treated and successfully eliminatd with chloquinie hydrochloride administered intramuscularly at a dose of 5 mg/kg base given at 0, 6, 24, 48, and 72 hours. Treatment also included a blood transfusion and intensive supportive care.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1983
Accession Number
ADA129457

Entities

People

  • John C. Donovan
  • Richard D. Montrey
  • Robert W. Wannemacher Jr.
  • William L. Thompson
  • William S. Stokes

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Animals
  • Blood
  • Blood Counts
  • Blood Transfusions
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Health Services
  • Hematologic Diseases
  • Immune System
  • Infection
  • Infectious Diseases
  • Laboratory Animals
  • Malaria
  • Parasitic Diseases
  • Therapy
  • Tissues

Fields of Study

  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Parasitology and Pharmacology of Malaria.