Characterization of the Chemical Constitution and Profile of Pharmacological Activity of PGB(x).

Abstract

The pharmacological studies conducted over the past four years have attempted to answer the following questions: (a) Does PGBx produce organ level effects that are expressions of PGBx's established mitochondrial actions? (b) Are the organ level effects related to PGBx's ability to act as a calcium iontophore? (c) In assessing its potential therapeutic utility, are there other actions of PGBx that are relevant? (d) Can an organ level bioassay be designed that is adapatble to the evaluation and comparison of biological activity of PGBx analogs and components? The results of these studies are summarized.

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Document Details

Document Type
Technical Report
Publication Date
May 31, 1983
Accession Number
ADA129524

Entities

People

  • A. M. Burkman
  • D. D. Miller
  • R. W. Doskotch

Organizations

  • Ohio State University

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Cardiac Arrhythmias
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Heart Conduction System
  • Lethal Dosage
  • Myocardial Ischemia
  • Pharmacology
  • Rodents
  • Veins

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Cardiovascular Physiology
  • Cellular and Molecular Pathways of Apoptosis.
  • Systems Analysis and Design