Regulation of Chromatin Function by Polyadenosine Diphosphoribosylation,
Abstract
The biological function of poly (ADP-R) based on its macromolecular properties is envisaged as a nucleic acid component of a cross linking system capable of promoting or inhibiting the regulatory effect of chromatin proteins on transcription. Two examples, the action of triiodothyronine and of chemical carcinogens illustrate this complex action of the homopolymer functioning as a protein modifier. Although DNA and RNA can be profitably studied in isolated systems without paying attention to poly (ADP-R), integration with cellular physiology makes it mandatory to include poly (ADP-R) as a nucleic acid that possesses exclusively regulatory function.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 07, 1982
- Accession Number
- ADA129675
Entities
People
- Ernest Kun
- Eva Kirsten
- George Jackowski
- Leonard Peller
- Takeyoshi Minaga
Organizations
- University of California, San Francisco