Pyridostigmine-Induced Cholinesterase Inhibition: Effects on the Ability to Work in the Heat,
Abstract
Adult, male rats (300-325 g) were treated with pyridostigmine bromide (n=22) or saline (n=22) to quantitate the effects of severe (64%) cholinesterase inhibition on the ability to work (9.14 m/min, level treadmill) in the heat (35 deg C). Pyridostigmine-treated rats had a mean endurance of 23 min while saline-treated animals ran for nearly 35 min (p<or=.001). Rates of rectal and skin temperature increments were significantly higher (p<or=.001) in pyridostigmine-treated rats as were water losses (p<or=.001). While exercise in the heat to hyperthermic exhaustion effected anticipated increments in circulating urea nitrogen, creatinine, lactate dehydrogenase, and potassium levels, pyridostigmine pretreatment had additive effects on lactate and creatine phosphokinase concentrations. Additionally, pyridostigmine effected a significant (p<or=.01) hyperglycemia prior to exercise. We concluded that pyridostigmine-induced cholinesterase inhibition had a variety of debilitating effects during work in the heat.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 27, 1983
- Accession Number
- ADA129717
Entities
People
- Milton Mager
- Ralph Francesconi
- Roger Hubbard
Organizations
- United States Army Research Institute of Environmental Medicine