Analysis of Flavivirus Replication.

Abstract

Flaviviruses cause significant human morbidity and mortality, but as yet little is known about the replication of these viruses. Our studies have indicated that replication of West Nile virus (WNV) in genetically resistant murine cells is characterized by a reduced infectivity yield and production of progeny enriched in DI particles. A mutant of WNV isolated from a persistently infected resistant culture can efficiently replicate in resistant cells.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1981
Accession Number
ADA130156

Entities

People

  • Margo A. Brinton

Organizations

  • Wistar Institute

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Animals
  • Biological Factors
  • Biomedical Research
  • Cells
  • Chemistry
  • Culture Techniques
  • Defective Viruses
  • Gel Electrophoresis
  • Infection
  • Interferon
  • Laboratory Animals
  • Medical Personnel
  • Proteins
  • Virion
  • Viruses
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology and Pathology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology