Immunologic Interrelationships of Coliform Heat-Labile and Heat-Stable Enterotoxins
Abstract
The goal of these studies is the development of an immunization program to prevent diarrheal disease due to intestinal contamination by enterotoxigenic strains of coliform bacteria. We have found that immunization with the polymyxin-release form of Escherichia coli heat-labile enterotoxin by means of a parenteral prime followed by peroral boosts yields the combination of maximum immediate and extended protection and demonstrated that this immunization regimen is totally protective when gnotobiotic rats are challenged by intestinal contamination with strains of E. coli which produce the heat-labile toxin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 15, 1980
- Accession Number
- ADA130592
Entities
People
- Frederick A. Klipstein
Organizations
- University of Rochester