Immunological Interrelationships of Coliform Heat-Labile and Heat-Stable Enterotoxins
Abstract
The goal of these studies is the development of an immunization program to prevent acute diarrheal disease due to intestinal contamination of enterotoxigeneic strains of Escherichia coli. We have demonstrated (a) that the holotoxin is the most immunogenic form of the E. coli heat-labile enterotoxin, (b) that immunization with this material protects rats against challenge with heterologous serotypes of E. coli, and (c) that the degree of protection is influenced by the route, schedule and dosage of both the primary and booster immunizations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1981
- Accession Number
- ADA130593
Entities
People
- Frederick A. Klipstein
Organizations
- University of Rochester