The Synthesis and Evaluation of 15-Keto-PGB1 Analogues.
Abstract
The reaction pathway for the oligomerization of 15-dehydro-PGB1, the PGBx precursor, has been determined to proceed by a Michael addition pathway involving multiple reaction sites. The resultant complexity of such oligomeric mixtures precludes the isolation of individual components from the complex PGBx mixture. As an alternative, procedures were developed to provide less complex mixtures in which oligomers as small as dimers and trimers exhibited activities comparable to PGBx. The dimers were isolated and fully characterized. Blocked 15-dehydro-PGB1 derivatives were also developed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1983
- Accession Number
- ADA130601
Entities
People
- George L. Nelson
Organizations
- University of Saint Joseph