Research and Development of Wound Dressing in Maxillofacial Trauma.
Abstract
Three kilograms of poly-L-((-)lactide have been synthesized for this contract and for Contract No. DAMD 17-80-C-0110. This polymer has a viscosity (R.S.V.) of 1.19 dl.g, a molecular weight (MWw) of 45,700 and a polydispersity of 2.14. Material from a previous contract was used for preliminary experiments. Avitene mat has been obtained from FMC which can be used as a collection element for the non-woven fabric. Povidone-iodine (PVP-I2) from Napp (Co.) is insoluble in methylene chloride. Other grades from BASF are more soluble and also more readily cleared by the kidneys. However, a mixed solvent is required for material preparation. Powders of polymer with lidocaine (HCl), etidocaine (HCl), benzocaine, and PVP-I2 have been prepared using a hammer mill and dry ice. All composites contained 20% drug before and after comminution. Small particle sizes of powder containing the anesthetics released the drug rapidly. A 600-425 micrometer fraction containing 20% etidocaine released 20% of the drug in oue hour, 48% in six hours, and 70% in 24 hours. Modifications of drug loading and drug from (e.g. free base, sulfate) are being considered. PVP-I2 is stable in the powder form, and 10% of the available iodine is found in the diffusion medium after one hour.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 1981
- Accession Number
- ADA130661
Entities
People
- David L. Williams
- James H. Kerrigan