Increased Mitochondrial Oxygen Consumption in the Hypermetabolic Injured Rat
Abstract
The rise in total body oxygen consumption after severe thermal injury is accompanied by an increase in visceral oxygen utilization and substrate turnover, in part to meet the metabolic demands of the wound. The increased heat production after injury is the consequence not of altered thermoregulatory drives, but of an elevated metabolic state. The extent of this increased heat production suggests that accelerated intracellular oxidative processes may be primarily functioning to produce heat rather than energy to be used for synthetic and transport reactions. To assess the cellular basis for this increased oxygen utilization, we examined the function of mitochondria isolated from the liver, the metabolically most active organ.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1982
- Accession Number
- ADA130994
Entities
People
- Arthur D. Mason Jr.
- Basil A. Pruitt Jr.
- Cleon W. Goodwin
Organizations
- United States Army Institute of Surgical Research