The Mechanism of Blood Function and Production After Injury.
Abstract
Protein depletion in rats is associated with hemoconcentrated diminution of red cell mass and loss of erythropoiesis. Restoration of nutrition by diet or total parenteral nutrition (TPN) is accompanied by weight gain and restoration of red cell mass. Intravenous repletion of both normal and protein depleted rats, unlike orally refed cohorts, was associated with elevated 2,3 diphosphoglycerate (2,3 DPG) values and anemia. It is postulated that elevated red blood cell 2,3 DPG values in the intravenously refed rats interacted with hemoglobin to enhance oxygen unloading, thereby lowering the hypoxic stimulus for erythropoietin production, and ablating the hypoxic stimulus to the kidney. Because of the lack of a hypoxic stimulus to the kidney, an aregenerative anemia persisted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1980
- Accession Number
- ADA131126
Entities
People
- George F. Sheldon
Organizations
- University of California, San Francisco