Immunologic Control of Diarrheal Disease Due to Enterotoxigenic Escherichia coli: Reactogenicity, Immunogenicity, and Efficacy Studies of Purified Escherichia coli (H10407 and B7A) Pili Vaccines
Abstract
Purified type 1 somatic pili vaccine from E. coli H10407 was given parenterally to 21 healthy adults. The vaccine was found to be non-reactogenic after one dose, gave some local reactions upon booster inoculation and was highly immunogenic. When challenged with virulent E. coli H10407, the attack rate in vaccines was significantly lower (2/6) than in controls (7/7) (p=0.04).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1979
- Accession Number
- ADA131309
Entities
People
- Myron M. Levine
Organizations
- University of Maryland, Baltimore