Studies on Typhus and Spotted Fever.
Abstract
The report deals with progress in the following: (1) In vitro studies of intracellular antirickettsial action and cytotoxic action on infected cells by supernatant fluids from stimulated human blood leukocytes. (2) Electron microscopic studies of mechanisms by which R. prowazekii circumvents the microbicidal action of human monocyte-derived macrophages in vitro and the events which lead to the intravacuolar destruction of immune serum opsonized rickettsiae. (3) In vivo studies in a R. mooseri-mouse model which demonstrates the failure of macrophages activated by classical CMI mechanisms to control rickettsial proliferation in the absence of antibodies. (4) In vivo studies, in a R. mooseri-mouse model which demonstrates that immune T-lymphocytes, but not immune serum, restrict rickettsial proliferation locally in the spleen.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1980
- Accession Number
- ADA131672
Entities
People
- Charles L. Wisseman Jr.
Organizations
- University of Maryland, Baltimore