Evaluation of the Embryotoxicity of JP-10 in the Rat

Abstract

The effect of JP-10, the major component of cruise missile fuel, on the development of embryonic rats was evaluated. Pregnant females were exposed via inhalation to 600 ppm or orally dosed with 250, 500 or 1000 mg JP-10/kg on gestation days 6-15. In a separate experiment both fetal and maternal blood levels of JP-10 were monitored during an inhalation exposure. Moderate signs of toxicity including tremors and convulsions were observed in the pregnant females receiving the higher doses. JP-10 was not selectively embryotoxic in the rat when administered by gavage or inhalation. Blood levels of JP-10 in the fetuses was about one half the maternal blood levels at steady state.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1983
Accession Number
ADA131764

Entities

People

  • K. C. Back
  • K. O. Yu
  • R. C. Inman
  • W. C. Keller

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abnormalities
  • Air Force
  • Biomedical Research
  • Blood
  • Body Weight
  • Cruise Missiles
  • Flow Rate
  • Hydrocarbons
  • Kidney Diseases
  • Oils
  • Plant Oils
  • Soft Tissues
  • Toxic Hazards
  • Toxicity
  • Urinary Tract
  • Vena Cava

Readers

  • Petroleum Engineering
  • Toxicology/Environmental Toxicology