The Effectiveness of Aprotinin in Blocking a Shock Factor of Pancreatic Origin from the Pig, Dog, or Monkey.

Abstract

Pancreatic shock factor (PSF) causes profound hypotension when injected into the species of origin (i.e. 'within species', pig PSF into the pig, etc.). Aprotinin, a proteolytic enzyme inhibitor, sucessfully blocked the PSF-induced hypotension 'within species' in the pig but did not alter the hypotension in the dog or monkey. This investigated by infusing PSF from either the pig, dog, or monkey into the other two species ('across species'). PSF was a hypotensive agent 'across species'; aprotinin blocked the hypotensive reaction in each 'across species' combination. Aprotinin is more effective as a blocking agent of PSF when infused 'across' then 'within species'. These species differences of the aprotinin blockade should be considered when designing treatment for shock associated with proteolytic enzymes.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1983
Accession Number
ADA132408

Entities

People

  • L. William Traverso

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Anesthesia
  • Animals
  • Arteries
  • Biological Sciences
  • Biomedical Research
  • Blood
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Enzyme Inhibitors
  • Experimental Design
  • Health Services
  • Materials
  • Military Research
  • Tissues
  • Veins

Fields of Study

  • Biology
  • Psychology

Readers

  • Microbial Pathology
  • Neuroscience
  • Parasitology and Pharmacology of Malaria.