Preparation of HI-6, HGG-12 and Toxogonin.
Abstract
Published procedures for synthesis of HI-6 result in a difficult-to handle intermediate, and a product contaminated with symmetrical impurities. Because of these comtaminants, purification requires repeated recrystallizations and leads to substantial material losses. We have discovered two methods that result in acceptable quality HI-6. Neither of these methods is optimized, however, and overall yields are low. We currently have 1150 g of 85% pure HI-6, prepared according to Good Manufacturing Practices (GMP). The preparation of Toxogonin is much easier than that of HI-6 because the former is symmetrical. We have 680 g of 99% pure and 400 g of 94% pure Toxogonin prepared according to GMP.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1983
- Accession Number
- ADA132484
Entities
People
- M. A. Geigel
- M. M. Broussard
Organizations
- SRI International