Chemical Characterization and Toxicological Evaluation of Airborne Mixtures. Inhalation Toxicology of Diesel Fuel Obscurant Aerosol in Sprague-Dawley Rats. Phase 1. Acute Exposures.
Abstract
Exposures of Sprague-Dawley rats to aerosolized diesel fuel in inhalation chambers are being conducted to determine the potential health effects of this visible obscurant. Data from the first phase of these exposures, establishment of maximum tolerated concentrations for single exposures, are reported here. Groups of rats of both sexes were exposed to concentrations of aerosol particles ranging from 2.7 to 16 mg/L for 2, 4, or 6 hours. Almost all deaths occurred within 48 hours of exposure. The only lesions observed at autopsy were in the respiratory tract; darkly reddened lungs, fluid in the trachea, and occasionally blood around the external nares. Mortality was highly correlated with the multiplication product of particulate concentration and duration exposure (p = 0.0001) and 83% of the variation in mortality was explained by the Ct product, based on analysis using arcsine transformation. Separate experiments were performed to establish dose-response relationships for two other endpoints: pulmonary free cell number after exposure and breathing pattern after exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1982
- Accession Number
- ADA132650
Entities
People
- Simon Lock
- Walden Dalbey
Organizations
- Oak Ridge National Laboratory