Fourteen-Day Subchronic Oral Toxicity Study of 4-Nitrophenyl Methyl (Phenyl) Phosphinate in Male and Female Rats.
Abstract
A short-term multidose oral toxicity study for 4-nitrophenyl methyl (phenyl) phospinate (MPP) was conducted as a preliminary test for a prolonged 90-day study. Four dose groups of male and female rats (1/2, 1/4, 1/8, and 1/6 of the LD50) were used. Rats were dosed daily by gastric gavage for 14 days. Necropsies and histological examinations were performed on all animals. Urinalysis, standard hematological measurements and an array of serum analyses were performed. In addition, plasma, red blood cell and brain acetylcholinesterase activities were determined. Blood and urine analyses indicated no compound related effects, except slightly depressed red blood cell acetylcholinesterase activity. The only compound related effects found in the histological examinations were gross changes in the digestive system in one or more male rats at the two highest dose levels.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1982
- Accession Number
- ADA132656
Entities
People
- Carolyn M. Lewis
- Glen E. Marrs
- Martha A. Hanes
- Paul P. Waring
- Paul W. Mellick
Organizations
- Letterman Army Hospital