Comparative Biochemistry and Metabolism. Part 2. Naphthalene Lung Toxicity
Abstract
Previous studies have shown that introperitoneal administration of naphthalene to mice results in dose-dependent necrosis of pulmonary bronchiolar epithelial cells but not in hepatic or renal damage. Several factors have supported a relationship between the cytochrome P-450 mediated formation of reactive naphthalene metabolites and the bronchiolar epithelial damage. Reactive metabolites from naphthalene become bound covalently to macromolecules in the lung in a dose and time dependent fashion and pretreatments which alter the severity of bronchiolar damage alter the pulmonary covalent binding in a parallel fashion. However, the observed target organ specificity for naphthalene-induced cytotoxicity is not reflected in the preferential covalent binding of reactive metabolites in the target tissue in vivo nor is it reflected in substantially higher rates of pose of the studies outlined in this annual report was to develop a method for examining the chemical nature of reactive metabolites produced in microsomes from target and nontarget tissues and to determine whether differences in the kinetics of formation of a particular reactive metabolite correlate with the highly species and organ specific toxicity of naphthalene.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1983
- Accession Number
- ADA132943
Entities
People
- Alan R. Buckpitt
Organizations
- University of California, Irvine