Hematologic Characterization of Naturally Occurring Malaria (Plasmodium inui) in Cynomolgus Monkeys (Macaca fascicularis)
Abstract
Twenty of 47 recently imported cynomolgus monkeys (Macaca fascicularis) were found to have malarial infections. The agent identified was Plasmodium inui. All infections were subclinical in nature. Parasitemias ranged from 10 to 900 parasites/mm (expn 3) of whole blood. Pre- and post-treatment hematologic values were evaluated following treatment with chloroquine. Treatment was effective in clearing parasitemias from 13 of 14 infected monkeys. Pre-treatment values of hematocrit, hemoglobin, and mean corpuscular volume were significantly different in infected animals compared to noninfected animals. While post-treatment hemoglobin and hematocrit values returned to noninfected control levels, mean corpuscular volume values of infected animals remained significantly lower in the post-treatment period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1983
- Accession Number
- ADA133841
Entities
People
- Harry Rozmiarek
- John C. Donovan
- Richard D. Montrey
- Williams S. Stokes
Organizations
- United States Army Medical Research Institute of Infectious Diseases