Humoral Control of Regional Blood Flow in Hemorrhagic Shock in Non-Resuscitated and Resuscitated Animals.

Abstract

In experiments in rabbits and primates we have: (1) Reaffirmed a prolonged reduction in blood volume and visceral organ flow for periods of at least 18 hours after resuscitation from hemorrhagic shock. (2) Shown that none of the readily identifiable humoral controls of blood pressure or vascular resistance are involved in this flow redistribution (i.e., renin/angiotensin, cathecholamines, thromboxane). (3) Demonstrate improved survival in shocked rabbits treated with ATP-MgC12. (4) Failed to demonstrate any change in mortality in shocked animals subjected to endorphin antagonism with naloxone. (5) Shown no favorable effect of resuscitation with fluorocarbons on survival in rabbits in hemorrhagic shock.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1982
Accession Number
ADA134407

Entities

People

  • J. Judson Mcnamara

Organizations

  • The Queen's Medical Center

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Flow
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Chemistry
  • Heart Rate
  • Hemorrhage
  • Hemorrhagic Shock
  • Laboratory Animals
  • Tissues
  • Veins

Fields of Study

  • Biology
  • Medicine

Readers

  • Fluid Mechanics and Fluid Dynamics.
  • Infectious Disease/Epidemiology
  • Trauma Surgery or Emergency Medicine.