Biochemical Basis of Virulence in Epidemic Typhus.
Abstract
The purpose of the project is to elucidate the biochemical basis of virulence in epidemic typhus. The basic method is a comparison of the E strain and Breninl strain (avirulent and virulent, respectively) of Rickettsia prowazekii in their interaction with the host defense system. Subsequent to the last annual report, work has focused on two areas (1) a study of the ability of virulent and avirulent Rickettsia prowazekii in the cytoplasm of macrophage-like cell lines which employed a fusion technology and (2) the preparation of a manuscript on the macrophage-like cell lines' ability to differentiate the virulent and avirulent typhus rickettsiae.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1983
- Accession Number
- ADA135430
Entities
People
- H. H. Winkler
Organizations
- University of South Alabama