Toxicokinetic Principles in Relation to Percutaneous Absorption and Cutaneous Toxicity
Abstract
At the foundation of the sciences of toxicology and pharmacology is the concept that coherent dose-response relationships exist for describing effects of chemicals on biological organisms. In one of several forms, dose-response curves for quantal effects are constructed by plotting the proportion of animals in a group responding with a particular effect on a y-axis, e.g., a dermal effect such as chloracne, versus the logarithm of dose on the x-axis. The resulting curve has a sigmoidal shape and usually progresses smoothly from no response at low concentration to 100% response at sufficiently high concentration. Although this is the usual shape for quantal dose-effect relationships, curves with anomalous shapes are not unknown, and such behavior usually gives significant information about mechanisms of the biological effect under investigation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1984
- Accession Number
- ADA136556
Entities
People
- M. E. Andersen
- W. C. Keller
Organizations
- Air Force Research Laboratory