The Role of Intestinal Bacteria in Acute Diarrheal Diseases
Abstract
This report describes investigations in these four major areas of research: (1) Reassessment of the infant rabbit model of E. coli colonization. (2) Testing of E. coli strains isolated from humans with diarrheal disease for enterotoxin production and presence of colonization-specific surface antigens. (3) Methodology for isolation of specific pili (i.e. surface antigens which function in colonization). Characterization of pili. Preparation of pili- specific antisera. (4) In vitro adhesion assays specific for recognition of E. coli strains which are potentially pathogenic for humans.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1977
- Accession Number
- ADA136706
Entities
People
- S. L. Gorbach
Organizations
- Tufts Medical Center