Acute Oral Toxicity of DMSO (Dimethyl Sulfoxide) Process Stream Samples in Male and Female Rats.
Abstract
The acute toxicities of a single oral dose of the DMSO process stream samples, DMSO Evaporator Sludge, DMSO Recycle Solvent, and Virgin DMSO, were determined in male and female albino Sprague-Dawley rats. The DMSO Evaporator Sludge and Virgin DMSO solutions produced no deaths in male or female rats at a limit dose level of 5.0 m1/kg. The DMSO Recycle Solvent was more toxic, and a LD(50) with 95 percent confidence limit was calculated by probit analysis. The DMSO Recycle Solvent LD(50) was 2.1 m1/kg in male rats, 95 percent confidence limit (1.5 m1/kg, 2.8 m1/kg), and 1.3 m1/kg in female rats, 95 percent confidence limit (1.0 m1/kg, 1.8 m1/kg).
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1983
- Accession Number
- ADA137309
Entities
People
- C. W. White
- G. E. Marrs Jr
- Janna Rodriguez
Organizations
- Letterman Army Hospital