HI-6: A Comparative Study of Various Samples,
Abstract
A comparison of the chemical purity, toxicology and efficacy of HI-6 (4-(aminocarbonyl) pyridino)methoxy)methyl)-2(hydroxyimino)methyl)-pyridinium dichloride) obtained from various sources was performed. There were no significant differences between HI-6 obtained from either Israel, Yugoslavia, The Netherlands or Canada regarding their efficacy, when combined with atropine, as an antidote of organophosphate poisoning. HI-6 obtained from Great Britain was significantly more toxic and less efficacious than any of the other HI-6 samples. In addition the results of this study showed that there was no significant difference between HI-6 prepared as a laboratory batch and HI-6 prepared commercially with regards to chemical purity, toxicology or efficacy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1983
- Accession Number
- ADA138252
Entities
People
- H. G. Thompson
- J. G. Clement
- P. A. Lockwood
Organizations
- Defence Research and Development Canada