Growth Media Dependent Characteristics of Neisseria meningitidis
Abstract
Four disease isolates of Neisseria meningitidis were characterized on the basis of their virulence in mice and sensitivity to antibiotics. Repeated subculturing of a virulent strain resulted in the loss of pili and extracellular material with the subsequent loss of virulence properties of the organism. Extracellular material associated with the virulent strain seems to play an important role in infection in mice. Strains resistant to sulfonamides were also found to be resistant to combination of sulfonamides with trimethoprim. This is a new finding. N. meningitidis showed an increased sensitivity to antibiotics on a chemically defined medium as compared to an enrichment medium. The changes were dependent on the nature of the growth medium and were reversible. This increased sensitivity of N. meningitidis to antibiotics on chemically defined media may be due to permeability changes occurring in the outer membranes of the organism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1983
- Accession Number
- ADA138304
Entities
People
- A. R. Bhatti
- J. Fildes
- L. A. White
- M. H. Knodel
- M. R. Spence