Anticholinesterase Effects on Number and Function of Brain Muscarinic Receptors and Central Cholinergic Activity: Drug Intervention.

Abstract

This study endeavors to elucidate the acute mechanisms adapted by the body to reduce cholinergic in order to fend off the toxic effects of anticholinesterase poisons. The effect of DDVP on rat brain acetylcholine content was characterized. The drug increased ACh in hemispheric structures (striatum, hippocampus, cortex) but not in cerebellum or midbrain-hindbrain. Pretreatments with atropine or reserpine only partially prevented the DDVP-induced increases. These and other experiments suggest that DDVP acted through a feedback mechanism secondarily to muscarinic receptor stimulation by the protected synaptic ACh. The feedback activation mediated by a monoamine leads to intraneuronal storage of ACh. Another fraction, perhaps smaller, accumulates extraneuronally and likely is responsible for the toxicity.

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Document Details

Document Type
Technical Report
Publication Date
Sep 30, 1983
Accession Number
ADA138746

Entities

People

  • H. Ladinsky

Organizations

  • Mario Negri Institute for Pharmacological Research

Tags

DTIC Thesaurus Topics

  • Air Force
  • Alkynes
  • Atropine
  • Biological Sciences
  • Brain
  • Central Nervous System
  • Cerebellum
  • Chemistry
  • Enzyme Inhibitors
  • Hippocampus
  • Medical Personnel
  • Nervous System
  • Norepinephrine
  • Reserpine
  • Security
  • Toxic Actions
  • Toxicity

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Neurotoxicology