Neutral Proteinase Activity in Skeletal Muscle from Thermally Injured Rats
Abstract
Male Sprague-Dawley rats that received 60% total body surface, full-thickness, scald burns on the dorsum and abdomen were used in this study. Neutral proteinase and Ca(2+)-activated neutral proteinase activities were measured in gastrocnemius and soleus muscles at 3 and 21 days after the thermal injury. Neutral proteinase activity decreased significantly in the soleus (50%) and gastrocnemius (46%) muscles on the third postburn day. Ca(2+)-activated neutral proteinase was unchanged at this time. Neutral proteinase and Ca(2+)-activated neutral proteinase activities were unaltered at 21 days postinjury. These results may reflect a protein-sparing effect on the third postburn day which could be an early intracellular change prior to an increase in selected enzyme proteins during the hypermetabolic phase after thermal injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1983
- Accession Number
- ADA138875
Entities
People
- Arthur D. Mason Jr.
- Basil A. Pruitt Jr.
- Cleon W. Goodwin
- David R. Strome
- James J. Newman
Organizations
- United States Army Institute of Surgical Research