Treatment of Mycobacterium intracellulare Infected Mice with Walter Reed Compound H
Abstract
The antimycobacterial activity of 21 thiosemicarbazone compounds on growth of strains of M. intracellulare was determined. The minimal inhibitory concentration for 5 of the compounds against strains growing in 7H9 broth was 1 mcg/m1 or less. One of these compounds, compound H, was chosen for further study and its effectiveness for treating M. intracellulare infected Swiss-Webster mice was determined. The drug was remarkably effective in eliminating organisms from the spleens and lungs of mice that had been infected by either intravenous or intraperitoneal injections of M. intracellulare serotype 12 (Trudeau D-673).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 25, 1980
- Accession Number
- ADA138877
Entities
People
- A. Y. Tsang
- J. K. Mcclatchy