Effect of Antiparasite Chemotherapeutic Agents on Immune Reactions.
Abstract
Cyclophosphamide has been shown to suppress primary response to both thymus dependent and thymus independent antigens. Under certain conditions, it also suppresses secondary responses. Studies reported here were designed to determine whether the suppression of anti-SRBC response by Cy was due to a lesion in macrophage function, B-cells or helper T-cells. Data from Berenbaum would indicate that B-lymphocytes which respond to thymus independent antigen, lipopolysaccharide are depleted by Cy. However, recent data point to the existence of several B-cell populations and in view of the selectivity of Cy for certain T-cell populations, it remains possible that B-cells responding to T-dependent antigen might be spared and the suppression of anti-SRBC response occurs via the depletion of helper T-cells. This was certainty our first impression, since Cy injected before antigen spared the response to another thymus independent antigen pneoumococcal polysaccharide. There have been conflicting data on the target of action of Cy in the suppression of anti-SRBC responses. Schwarze has suggested that suppression of anti-SRBC response by Cy is entirely due to its effect on helper T-cells. By contrast, Shand has provided data by using microsonially activated Cy in vitro that both TH and B-cells are damaged by Cy, although there was some preferential damage to B-cells when a higher concentration of Cy was used. Both studies cited above are subject to criticisms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1981
- Accession Number
- ADA138923
Entities
People
- A. Ghaffar
Organizations
- University of South Carolina