Genetic and Molecular Studies of the Phlebotomus Fever Group of Viruses.

Abstract

Studies supported by this contract have reported the characterization of the structural components of several Phlebotomus fever serogroup viruses (viral polypeptides and RNA species). The viruses studied include Punta Toro (PT), Karimabad (KAR), Chagres (CHG), Sandfly fever Sicilian (SFS Tesh and Sabin isolates). Sandfly Fever Naples (SFN), Rift Valley Fever (RVF), Phlebotomus 3 virus (PHL 3), Icoraci (ICO) and Buenaventura (BUI) viruses. With the demonstration of a tripartite RNA genome, genetic analyses were also undertaken in order to determine the coding strategies of the 3 RNA species and determine if recombinant viruses could be obtained and used for vaccine purposes. The coding strategy of the 3 RNA species are being investigated with the goal of characterizing the epitopes on viral antigens that elicit and interact with neutralizing antigens. Such goals are being realized by cloning and sequencing studies.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1983
Accession Number
ADA139536

Entities

People

  • D. H. L. Bishop

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antigens
  • Bunyaviridae
  • Civilian Personnel
  • Genetic Code
  • Medical Personnel
  • Microbiology
  • Mrna
  • Phlebotomus Fever
  • Ribonucleic Acids
  • Rift Valley Fever
  • Rift Valleys
  • Rna Viruses
  • Structural Components
  • Vaccines
  • Virology
  • Viruses

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology