Studies of Altered Response to Infection Induced by Thermal Injury.
Abstract
In summary, our laboratory has substantial data indicating that a monocyte defect does appear in severely burned patients who will eventually develop severe or fatal septicemia. This loss of patient monocyte function appears to correlate with a development of excessive T suppressor cells and mitogen hyporesponsiveness. Our preliminary data from a murine system seem to support that unbalancing of the immune network toward too much regulation (ie, increased T suppressor cells) is preceded by, and is probably a result of, loss of monocyte function.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1980
- Accession Number
- ADA140054
Entities
People
- C. L. Miller
Organizations
- University of California, San Francisco