Effects of Hematoporphyrin (HPD) and a Chemiluminescence System on the Growth of Transplanted Tumors in C3H/HeJ Mice

Abstract

Photoradiation therapy is emerging as a promising technique for combating cancer. Fundamentally, this approach consists of two steps: (1) hematoporphyrin derivative (HPD) is used to selectively sensitize cancer cells to visible light; (2) after an appropriate time interval, light is introduced into the tumor via a laser-fiber optic system to trigger the cytotoxic action of HPD. The present investigation was initiated to determine the therapeutic potential of HPD in combination with a chemiluminescent activator in treating mice which had been transplanted with tumors.

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Document Details

Document Type
Technical Report
Publication Date
Apr 06, 1984
Accession Number
ADA140058

Entities

People

  • A. P. Schaap
  • C. Amsterdamsky
  • F. W. Hetzel
  • J. D. Mcmahon
  • M. D. O'hara
  • M. J. Phillip

Organizations

  • Wayne State University

Tags

Communities of Interest

  • Counter IED
  • Energy and Power Technologies
  • Weapons Technologies

DTIC Thesaurus Topics

  • California
  • Cancer
  • Chemistry
  • Health Services
  • Military Research
  • Neoplasms
  • New Hampshire
  • New Jersey
  • Oncology
  • Oxygen
  • Phototherapy
  • Porphyrins
  • Rocket Oxidizers
  • Therapy
  • Time Intervals
  • United States
  • Visible Spectra

Fields of Study

  • Chemistry
  • Medicine
  • Physics

Readers

  • Chemistry (specifically Chemical Fluorescence)
  • Immunology and Pathology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech
  • Directed Energy