The Synthesis and Study of New Ribavirin Derivatives and Related Nucleoside Azole Carboxamides as Agents Active against RNA Viruses.
Abstract
In an effort to improve the antiviral potency of ribavirin, several selected derivatives of ribavirin have been prepared. A number of heterocycles and nucleosides in the 1,2,3-triazole, 1,2,4-triazole, imidazole, pyrazole and purine ring system have also been prepared to study the structure-activity relationship. New and improved synthetic methods, and isolation techniques have been developed during the course of this synthetic study. Most of the compounds synthesized were tested at the U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, against RVFV, VEE, PICH, YF and SF viruses in vitro as well as in vivo. Of the compounds tested, in parallel with ribavirin, ribavirin 3',5'-cyclic phosphate exhibited superior in vivo activity against VEE.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1981
- Accession Number
- ADA140106
Entities
People
- G. R. Revankar
- R. K. Robins
Organizations
- Brigham Young University