Development of Vaccines to Prevent Wound Infections Due to Anerobic Bacteria
Abstract
Anaerobic bacteria are common causes of infections resulting from wounds and bacteroides fragilis is the most likely of the various anaerobes to be isolated in serious infections. Clearly this organism is also involved in the pathogenesis of experimental intraabdominal infection and abscess formation. During this year major advances were made in defining the chemical nature of the B. fragilis capsular polysaccharide. It is a complex carbohydrate with 10 known monosaccharide constituents. We developed methods of growing and extracting this antigen which improved our yields by twenty fold. We have shown that the chemical constituents are reproducibly present from lot to lot with only minor variation in quantitative composition. Another important advance which occurred this year was demonstrating that our findings of immunization and spleen cell dependent transfer of immunity could be verified in another animal species (mouse). Finally, we have demonstrated that B. fragilis may play an important role in pelvic inflammatory disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1981
- Accession Number
- ADA140116
Entities
People
- Dennis L Kasper