Distribution and Characterization of Antigens Found in Subcellular Fractions of African Trypanosomes.
Abstract
This report describes the experiments to determine the subcellular localization of antigens in the African trypanosome Trypanosoma rhodesiense. Most of the antigenic components are associated with the surface membrane and flagellar pocket membrane. One prominent lysosomal antigen is present. At least 5 of the flagellar pocket antigens are glycoprotein and two of these display identical electrophoretic mobilities with surface membrane glycoproteins. Preliminary experiments show the surface membrane and lysosomal fractions to be the most protective against challenge infection with T. rhodesiense. The lysosomal flagellar pocket membrane fractions were also protective. Neither the promitochondrial or glycosomal fraction appeared particularly antigenic or to have protective potential.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1981
- Accession Number
- ADA140121
Entities
People
- J. Mclaughlin
Organizations
- University of Miami