Cardio-Pulmonary Response to Shock.
Abstract
Pressure breathing and particularly end-expiratory pressure will induce the pulmonary production of prostaglandins (PG). These PGs regulate cardiac contractility and the release of plasmin mediated fibrinolytic activity. A high molecular weight protein has been tentatively identified as the circulating negative inotropic agent whose production is stimulated by PG synthesis during end-expiratory pressure. The large amount of prostacyclin (PGI2) secreted by the lungs in response to surgery may protect against microaggregate entrapment and damage of the lungs. PGI2 infusion is effective therapy for experimental pulmonary embolism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1979
- Accession Number
- ADA140135
Entities
People
- H. B. Hechtman
Organizations
- Harvard Medical School