Acute Infectious Disease,
Abstract
The development of acute generalized infectious illnesses and serious inflammatory reactions is accompanied by the occurrence of a large number of interrelated host defensive measures. These constitute the generalized acute-phase response to infection, inflammatory states, or complex trauma. These responses include the development of fever and hypermetabolism, the production of a leukocytic response, the accelerated proteolysis of skeletal muscle, the generation of free amino acids from body somatic protein catabolism, the production of a number of hormones, the synthesis by the liver of acute-phase reactant proteins and of various intracellular enzymes, the acceleration within the liver of gluconeogenesis and lipogenesis with a relative suppression of ketogenesis, the redistribution and/or sequestration of various trace elements, and, importantly, the stimulation of immune system activity. These components of the acute-phase generalized, nonspecific metabolic response to acute infection are triggered by the release from activated monocytes and tissue macrophages of endogenous mediators which are currently grouped under the term Interleukin-l.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 23, 1984
- Accession Number
- ADA140255
Entities
People
- W. R. Beisel
Organizations
- United States Army Medical Research Institute of Infectious Diseases